ICD-10-CM Book 2025 Edition

Chapters  /  Chapter 21  /  Z17  /  Z17
Z17 Estrogen, and other hormones and factors receptor status
Notes Use one code, as available, for each receptor: Z17.0, Z17.1, Z17.2-, Z17.3-
CodeFirst malignant neoplasm, such as:
malignant neoplasm of breast (C50.-)
malignant neoplasm of ovary (C56.-)
Z17.0 Estrogen receptor positive status [ER+]
nonPrimary Yes
Z17.1 Estrogen receptor negative status [ER-]
nonPrimary Yes
Z17.2 Progesterone receptor status
Z17.21 Progesterone receptor positive status
PR+
Z17.22 Progesterone receptor negative status
PR-
Z17.3 Human epidermal growth factor 2 receptor
Z17.31 Human epidermal growth factor receptor 2 positive status
HER2+
Z17.32 Human epidermal growth factor receptor 2 negative status
HER2-
Z17.4 Combined receptor status
Notes Assign a code from subcategory Z17.4- when only a combined receptor status is documented
Z17.41 Hormone receptor positive
HR+
Z17.410 Hormone receptor positive with human epidermal growth factor receptor 2 positive status
HR+ with HER2+
Z17.411 Hormone receptor positive with human epidermal growth factor receptor 2 negative status
HR+ with HER2-
Z17.42 Hormone receptor negative
HR-
Z17.420 Hormone receptor negative with human epidermal growth factor receptor 2 positive status
HR- with HER2+
Z17.421 Hormone receptor negative with human epidermal growth factor receptor 2 negative status
HR- with HER2-
TNBC
Triple negative breast cancer