ICD-10-CM Book 2025 Edition

Chapters  /  Chapter 21  /  Z16  /  Z16
Z16 Resistance to antimicrobial drugs
Notes The codes in this category are provided for use as additional codes to identify the resistance and non-responsiveness of a condition to antimicrobial drugs.
CodeFirst the infection
Excludes1 Methicillin resistant Staphylococcus aureus infection (A49.02)
Methicillin resistant Staphylococcus aureus pneumonia (J15.212)
Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02)
Z16.1 Resistance to beta lactam antibiotics
Z16.10 Resistance to unspecified beta lactam antibiotics
nonPrimary Yes
Z16.11 Resistance to penicillins
Resistance to amoxicillin
Resistance to ampicillin
nonPrimary Yes
Z16.12 Extended spectrum beta lactamase (ESBL) resistance
Excludes2 Methicillin resistant Staphylococcus aureus infection in diseases classified elsewhere (B95.62)
nonPrimary Yes
Z16.13 Resistance to carbapenem
Z16.19 Resistance to other specified beta lactam antibiotics
Resistance to cephalosporins
nonPrimary Yes
Z16.2 Resistance to other antibiotics
Z16.20 Resistance to unspecified antibiotic
Resistance to antibiotics NOS
nonPrimary Yes
Z16.21 Resistance to vancomycin
nonPrimary Yes
Z16.22 Resistance to vancomycin related antibiotics
nonPrimary Yes
Z16.23 Resistance to quinolones and fluoroquinolones
nonPrimary Yes
Z16.24 Resistance to multiple antibiotics
nonPrimary Yes
Z16.29 Resistance to other single specified antibiotic
Resistance to aminoglycosides
Resistance to macrolides
Resistance to sulfonamides
Resistance to tetracyclines
nonPrimary Yes
Z16.3 Resistance to other antimicrobial drugs
Excludes1 resistance to antibiotics (Z16.1-, Z16.2-)
Z16.30 Resistance to unspecified antimicrobial drugs
Drug resistance NOS
nonPrimary Yes
Z16.31 Resistance to antiparasitic drug(s)
Resistance to quinine and related compounds
nonPrimary Yes
Z16.32 Resistance to antifungal drug(s)
nonPrimary Yes
Z16.33 Resistance to antiviral drug(s)
nonPrimary Yes
Z16.34 Resistance to antimycobacterial drug(s)
Resistance to tuberculostatics
Z16.341 Resistance to single antimycobacterial drug
Resistance to antimycobacterial drug NOS
nonPrimary Yes
Z16.342 Resistance to multiple antimycobacterial drugs
nonPrimary Yes
Z16.35 Resistance to multiple antimicrobial drugs
Excludes1 Resistance to multiple antibiotics only (Z16.24)
nonPrimary Yes
Z16.39 Resistance to other specified antimicrobial drug
nonPrimary Yes